JUMPSTART EX is a true nootropic smart formula, precisely crafted to be easier on the body as it intelligently helps optimize energy, focus and mood. We went to great lengths to ensure this is the healthiest, easiest, and most effective way to get an instant pick-me-up in both body and mind. (See below for usage.)
The JUMPSTART formula affects three distinct but complementary areas -- energy / focus, mood, and support.
Guarana is a South American berry that contains very high concentrations of caffeine (guaranine) and is used as a stimulant and appetite suppressant. For thousands of years, natives of the Amazon used the seed extract to help maintain stamina and physical endurance. Traditionally it was also used to assist in the relief of various ailments such as stress and nervous tension, weight control, headaches and hangovers. It is believed that due to the tannins and polyphenols attached to the caffeine molecule in its structure, it absorbs slower and causes less stomach irritation than caffeine from coffee. One study in 2006 at the University of Northumbria, showed evidence that guarana positively effected focus, memory and mood / disposition.
Anhydrous Caffeine has proven in a plethora of studies to have a positive effect on mood, endurance, performance, and focus. What is most interesting about the caffeine molecule is how it synergizes with other compounds. Studies have shown, for instance, enhanced beneficial effects when caffeine is combined with L-theanine, as well as l-tyrosine, and even its cousin, guarana.
Siberian Ginseng (Eleuthero) has been used for centuries to help enhance sexual and athletic performance as well as boost the immune system. This herb was hailed last century as an "adaptogenic" (stress-protective) marvel. In a study of 36 children ranging in age from 3 to 17 years old, Ginseng was administered twice a day on an empty stomach for 4 weeks. At the end of the study, more than 70 percent of patients had experienced improvement in energy levels and on a widely used measure of attention problem symptoms (Lyon MR et al 2001).
Acetyl-L-Carnitine (ALC) is an amino acid that supplies energy resources to mitochondria and is used to turn fat into energy. Although the body produces enough of its own ALC, supplementation improves the ability of certain tissues to produce energy, and has been shown in clinical studies to benefit cognitive ability, memory and mood.
L-Tyrosine is a non-essential amino acid synthesized in the body from phenylalanine. It is an important nutritional ingredient and factor for biosynthesis of the brain neurotransmitters epinephrine, norepinephrine, and dopamine (key to positive mood.) By promoting the production of "feel-good" chemicals in the brain, tyrosine is very beneficial to improving mood and disposition.
Tyrosine is also used to produce one of the major hormones, thyroxin, which plays an important role in controlling metabolic rate, skin health, mental health, and growth rate. Tyrosine has been tested on humans for increasing their endurance to anxiety and stress under fatigue. It was proven in research studies that tyrosine supplementation results in increased performance over a control group (Avraham et al. 2001).
L-Theanine, derived from green tea, is an amino acid that has a direct influence on brain activity, such as balancing, focusing, and reducing stress, increasing production of neurotransmitters, and effecting glutamate levels. At higher doses, it has the ability to relax the mind without causing drowsiness. Research has shown that L-theanine counteracts the jittery, speed-like effects of caffeine without reducing its mind-energizing, or fat-burning features. It is particularly helpful when combined with caffeine in supplements for this ability to balance "cellular nervousness."
L-theanine's benefits on mood are now well-accepted and it has actually been patented as a mood enhancer. (US Patent Application 20040171624; Japanese Patent Application 2001-253740.) Furthermore, stress hormones, common in our modern day life, cause imbalances in brain chemistry that disrupt production of serotonin, dopamine, norepinephrine, and other key brain chemicals. Drugs that suppress these stress hormones (glucocorticoids) are used as treatments for depression. However, research is showing that people who are depressed also have glutamate levels that are out of balance. Preliminary studies suggest that glutamate antagonists like L-theanine, which block certain signals in the brain activated by glutamate, may be as effective as antidepressants (Functional antagonists at the NMDA receptor complex exhibit antidepressant actions. Eur J Pharmacol. 1990 Aug 21;185(1):1-10.)
A handful of studies have also looked at the combination of L-theanine and caffeine on various aspects of cognition and mood (eg, alertness, attention.) For instance, one study compared the effect of caffeine with and without L-theanine on cognition and mood in 27 participants. Researchers gave participants placebo, caffeine, or caffeine plus L-theanine and measured their performance on several cognitive tests at baseline and then at 60 and 90 minutes after treatment. They found that the combination of caffeine and L-theanine improved speed and accuracy in an attention-switching task, as well as reduced the likelihood of distraction during a memory task. JUMPSTART EX takes full advantage of this research.
One study measured alpha activity in the brain, which plays an important role in attention. Thirty-five participants were given either 50 mg of L-theanine or placebo. Electroencephalogram (EEG) tests were done at baseline and then at specified times afterwards (45, 60, 75, 90, and 105 minutes). Researchers found that there was a greater increase in alpha activity in those who took L-theanine compared to placebo, demonstrating that the amino acid had an effect on the participants’ general state of mental alertness and arousal.
Acetyl-L-Carnitine, as mentioned above, also influences mood. Several studies have researched carnitines role in affecting mood. One double-blind study of 60 seniors with mild depression found that treatment with ALC daily over a 2-month period significantly improved symptoms as compared to placebo.
DMAE, dimethylaminoethanol, is exceptionally beneficial in helping increase the brain's ability to produce neurotransmitters. Also referred to as a “cholinergic” (similar to choline), DMAE increases the levels of the acetylcholine, a chemical in the brain that regulates mental function. Results in clinical studies have shown that DMAE positively benefits focus and mental clarity as well as mood. One German sudy reported that "DMAE can be interpreted to induce a psychophysiological state of better feeling of wellbeing on both levels of analysis mood and electrical pattern of brain activity in subjects suffering from borderline emotional disturbance."
Whenever you increase your energy levels and metabolism, you add stress to your body. This is not necessarily a bad thing, as any athlete will tell you, but we added specific adaptogens and support nutrients to ensure that the stress is mitigated and you feel robust.
Rhodiola Rosea is an excellent adaptogen which helps supports the adrenal glands, working with the body to reduce stress while boosting energy, balancing the stimulants so as to not overtax the system. One particularly interesting aspect of rhodiola is that it appears to work differently within the body than other adaptogens -- the best known of which is the very popular herb Siberian ginseng. Rhodiola's unique mechanism of action excites researchers because it means this herb may be able to provide a therapeutic alternative to established adaptogens, making an effective synergizing agent.
Schizandra (Schizandra chinensis) of the family Schizandraceae, is a creeping vine with small red berries that is native to Northern China. As a traditional medicinal herb, schizandra, called Wu-wei-tzu in China, has been used as a tonic for the treatment of chronic fatigue. Studies conducted on schizandra's effects have noted that the herb has a stimulating effect in low doses (Pharmacological studies on Schizandra fruit. I. General pharmacological effects of gomisin A and schizandrin (author transl). Maeda S, Sudo K, Aburada M, Ikeya Y, Taguchi H, Yoshioka I, Harada M.)
Magnesium, Vitamin B3, B6, B12, and C are all critically involved in numerous functions in the body including being direct effectors of cognitive function. A recent laboratory study from the Massachusetts Institute of Technology reveals that an adequate amount of magnesium is necessary to maintain the "plasticity" of synapses - the connectors that move information from neuron to neuron in the brain. When synapses are flexible to change, learning and memory are enhanced. Magnesium is involved in more than 300 metabolic reactions. Other conditions that have been associated with a magnesium deficiency include depression, anxiety and attention deficit disorder. Research suggest low levels of magnesium are associated with attention problems (Departments of Obstetrics and Gynecology and Neurology, Georgetown University Medical Center, Oct 2000.) In fact, magnesium has been called the 'miracle nutrient' by some for its many valuable benefits.
Vitamin B in its various forms has many functions in the body, including assisting in the synthesis of neurotransmitters and forming myelin, which protect nerves. At least three studies have demonstrated that the combination of magnesium and vitamin B6 improved behavior, decreased anxiety and aggression, and improved mobility among subjects with focus problems (Nogovitsina Mousain-Bosc M et al 2004).
Siberian Ginseng as mentioned above, has positive benefits as a boost to the immune system and has been hailed as an "adaptogenic" (stress-protective) marvel. In 1991 the German Commission E (the European authority on the use of plants in healing) made it official by declaring that it was highly effective in boosting the immune system.
Bioperine is an effector of other ingredients. It is known to have enhancing and synergizing properties and when used in a mix of ingredients, increases the interacting potency of each.
Usage (see usage page for complete details):
Each capsule contains 750mg, with a single dose being 2 capsules for the average person. Given the differences in physiology and lifestyle, we recommend 1 - 2 capsules to start, increasing as indicated by results. In general, the larger your body size, the more required. A rough guide is 1 capsule for each 80 lbs of body weight. Do not exceed 4 capsules in 24 hours. See our usage page for more details and warnings.
Our manufacturing plant meets or exceeds the FDA's GMP (Good Manufacturing Practices) Standards. This is a very important element in assuring you that we produce the best quality products. We guarantee the highest criteria of purity, potency, consistency and quality. According to GMP, each of our products must pass 26 steps from raw material to finished product. For dietary supplements, many of these steps or processes are not required by law. We have chosen to follow all 26 steps for quality assurance and control because we are committed to providing you with the very best health products.
Our highly experienced team of production professionals ensure every quality standard is consistently met. They painstakingly research each raw ingredient to assure the highest potency and quality, and concomitant interactions for maximum synergy (what separates professional supplement makers from the marketers.) Our nutritional products are designed for the new century, using technology and nature creatively, and are safe, effective, life-improving, and made with care, passion and love.
As a synergistic blend, JUMPSTART EX is a remarkable formulation. Just one dose and you'll feel fully charged and ready to be at your best. We believe it's the healthiest and the most effective energy, focus and mood boosting product you'll ever use.